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Software

QUMPHY Software package

At the core of this project stands the development of measures to quantify the uncertainties associated with machine learning (ML) algorithms applied to medical problems, in particular the analysis and processing of photoplethysmography (PPG) signals. To achieve this the following tasks will be addressed: (i) benchmark datasets will be generated using publicly available in vivo, in vitro and synthetic data (ii) different ML models and uncertainty quantification (UQ) methods will be used to analyse the processing of the PPG signals and specify the associated uncertainty and (iii) a good practice guide with accompanying software repository showcasing the used models, methods and benchmarks will be developed and made publicly available.

 

Articles (Peer Reviewed)

  1. AD Rodway, L Hanna, J Harris, R Jarrett, C Allan,  F Pazos Casal, BCT Field, MB Whyte, N Ntagiantas, I Walton, A Pankhania, SS Skene,  GD Maytham, C Heiss, "Prognostic and predictive value of ultrasound-based estimated ankle brachial pressure index at early follow-up after endovascular revascularization of chronic limb-threatening ischaemia: a prospective,  single-centre,  service evaluation", eClinicalMedicine 68(102410), 2024
    published: https://doi.org/10.1016/j.eclinm.2023.102410
  2. M Rinkevičius, J Lazaro, E Gil, P Laguna, PH Charlton, R Bailon, V Marozas, "Obstructive Sleep Apnea Characterization: A Multimodal Cross-Recurrence-Based Approach for Investigating Atrial Fibrillation", IEEE Journal of Biomedical and Health Informatics, 2024
    published: https://doi.org/10.1109/JBHI.2024.3428845
  3. L Hannab, AD Rodwaya, P Garchac, L Maynardc, J Sivayogic, O Schlagere, J Madaricf, V Boch, L Buschg, MB Whytec, SS Skenec, J Harrisi, C Heiss, "Safety and procedural success of daycase-based endovascular procedures in lower extremity arteries of patients with peripheral artery disease: a systematic review and meta-analysis", eClinicalMedicine 75(102788), 2024
    published: https://doi.org/10.1016/j.eclinm.2024.102788
  4. P Charlton, V Marozas, E Mejía-Mejía, PA Kyriacou, J Mant, "Determinants of photoplethysmography signal quality at the wrist", PLOS Digital Health 6(e0000585), 2025
    published: http://dx.doi.org/10.1371/journal.pdig.0000585
  5. C Teichert, U Hackstein, T Krüger, S Bernhard, "Noninvasive detection of lower extremity artery disease using multi-site photoplethysmographic signals and machine learning", npj Biosensing 1(2), 2025
    published: https://doi.org/10.1038/s44328-025-00044-z
  6. M Moulaeifard, PH Charlton, N Strodthoff, "Generalizable deep learning for photoplethysmography-based blood pressure estimation - A Benchmarking Study", Machine Learning: Health, 2025
    published: http://dx.doi.org/10.1088/3049-477X/ae01a8
  7. C Bench, V Desai, M Moulaeifard, N Strodthoff, P Aston, A Thompson, "Uncertainty quantification with approximate variational learning for wearable photoplethysmography prediction tasks", Mach. Learn.: Health 1 015013, 2025
    published:  https://www.doi.org/10.1088/3049-477X/ae0b74
  8. M Moulaeifard, L Coquelin, M Rinkevičius, A Sološenko, O Pfeffer, C Bench, N Hegemann, S Vardanega, M Nandi, J Alastruey, C Heiss, V Marozas, A Thompson, PJ Aston, PH Charlton, N Strodthoff, "Machine-learning for photoplethysmography analysis: Benchmarking feature, image, and signal-based approaches", Biomedical Signal Processing and Control 120(A), 2026
    published: https://doi.org/10.1016/j.bspc.2026.109831
  9. C Bench, O Pfeffer, V Desai, M Moulaeifard, L Coquelin, PH Charlton, N Strodthoff, N Hegemann, PJ Aston, A Thompson, "A systematic evaluation of uncertainty quantification techniques in deep learning: a case study in photoplethysmography signal analysis", preprint available
    preprint: https://arxiv.org/abs/2511.00301

Articles (Other)

  1. PH Charlton, PA Kyriacou, "Wearable Photoplethysmography: Current Status and Future Challenges", 2023 IEEE/ACM Conference on Connected Health: Applications, Systems and Engineering Technologies (CHASE), 2023
    published: https://ieeexplore.ieee.org/abstract/document/10364195
  2. N Strodthoff, "Open Science to Foster Progress in Automatic ECG Analysis: Status and Future Directions", 2024 Computing in Cardiology Conference (51), 2024
    published: https://doi.org/10.22489/CinC.2024.057
  3. M Rinkevičius, PH Charlton, V Marozas, "Uncertainty in Photoplethysmography-Based Cuffless Blood Pressure Trend Monitoring: A Personalized Approach", 2024 Computing in Cardiology Conference (51), 2024
    published: https://doi.org/10.22489/CinC.2024.098
  4. CA Bench, N Strodthoff, M Moulaeifard, P Aston, AJ Thompson, "Towards Trustworthy Atrial Fibrillation Classification from Wearables Data: Quantifying Model Uncertainty", 2024 Computing in Cardiology Conference (51), 2024
    published: https://doi.org/10.22489/CinC.2024.068
  5. P Aston, "Does Skin Tone Affect Machine Learning Classification Accuracy Applied to Photoplethysmography Signals?", 2024 Computing in Cardiology Conference (51), 2024
    published: https://doi.org/10.22489/CinC.2024.038